salk institute vaccine spike protein

By: Express News Service Spikes created inside cells from mRNA are degraded before they exit the cell through the MCH mechanism and the result it the standard immune system hand off is made to fully consume and degrade these protein peptides. With mRNA vaccine technology the spike protein is made inside the cellular machinery, but it goes on to be destroyed once it is made inside the cells and CAN NOT EXIT the Cell intact. Pamela Maher Seeking treatments for Alzheimers disease. This suggests a successful immune response doesn't concentrate on the RBD. . CDC.gov. It is now known that many of the toxid effects of being infected by SARS COV 2 stem directly from the spike protein ie the spike protein itself is a pathogen. This has implications for many behaviors, including when its best to eat, exercise, and take medications. Adam MercyMercy School | Scientific Media, Check out this UK model, which predicts on page 10 #32 that up to 70% of COVID-19 hospitalizations/deaths this fall will be among the twice vaccinated. American College of Obstetricians and Gynecologists. Most use a recombinant spike glycoprotein: either mRNA based (the Moderna and Pfizer-BioNTech vaccines), via an adenovirus vector (the Oxford-AstraZeneca, CanSino, and Johnson & Johnson vaccines), or via injection of the protein itself (the Novavax vaccine). over our editorial decisions, and the views expressed in our articles do not necessarily reflect the views of the foundation. The vaccine-derived spike protein enters the bloodstream and accumulates at harmful levels in tissues, such as the spleen, bone marrow, liver, adrenal glands, and ovaries. The new technology treatments give mRNA to teach your own cells to make the spike proteins. 31 Mar 2021. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls. Taken together, it looks as if Operation Warp Speed delivered a questionable vaccine but to recoup their losses Big Pharma still needs to put the jab into peoples arms even though much more is unknown than known! 128, No. a San Diego biotechnology company to develop COVID-19 Does that mean people who are vaccinated face the same health risks as COVID-19 itself? Each of those are thought to induce more than 2000 spike proteins in the cells they enter. We are slowly getting to the right conclusion. 31 Mar 2021. Email address is optional. 5 Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA (C.R.S., G.S.S.). You retards fell asleep in biology 101 of high school and it shows. So by vaccinating people we are inadvertently inoculating them with a toxin., , Bridles research focuses on biotherapies for the treatment of cancers and the way organisms respond to viruses. And it is located upon a plateau. Nonstandard Abbreviation and Acronyms Data Availability 03 In collaboration with UC San Diego, USC and Sanford Research from the lab of Professor Satchin Panda has found that the majority of our genes follow a day/night rhythm in many tissue types and brain regions. Accessed 29 June 2021. There is no screening or vetting of the report and, to determine if the vaccine was responsible for the problem. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827936/#:~:text=SARS%2DCoV%2D2%20uses%20its%20viral%20membrane%20fusion%20protein%2C,(ARDS)%20%5B5%5D. It is not true that spike proteins cant exit cells, because reactions in your cells do not happen immediately. Hundreds of millions of COVID-19 vaccine doses have been administered safely in the United States in the last six months. 5 May 2021. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.Science. It also means that while naturally acquired immunity from the infection of SARS COv 2 will have targets from all different parts of the virus, the antibodies produced by the vaccine will only be active for small fragments of the transfigured spike protein induced by the vaccine mRNA. See: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/975909/S1182_SPI-M-O_Summary_of_modelling_of_easing_roadmap_step_2_restrictions.pdf. Bridle is taking our results and completely misinterpreting them, said David R. Walt, a member of the faculty at Harvard Medical School and of Harvards Wyss Institute for Biologically Inspired Engineering, who co-authored a study that found circulating SARS-CoV-2 vaccine antigen in the plasma of vaccine recipients. of an individuals COVID-19 infection and limiting the virus If a burgler, theoretically, is born inside your house and cannot get out alive and is killed by the residents, there is no damage and no damage in the future at other houses. A Facebook post from the NZ Outdoors Party, which attracted 3256 votes in the 2020 election, draws on the same study to suggest mRNA vaccines "take over cells to manufacture the deadly (spike protein) toxin and this spread throughout much of the body". Alan Saghatelian and Joseph Noel are exploiting the atomic This article is a reprint of what I assume is the original source here: https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/. It is incredibly safe., A second study Bridle uses to support his claims is one by Pfizer. COVID vaccines and breastfeeding: what the data say. Nature. inhibitory factor) plays a role in pancreatic cancer. Experts say the spike protein created by the human body after mRNA vaccination is different than the SARS-CoV-2 spike protein. 2021 Oct 13;2021.10.12.464152. doi: 10.1101/2021.10.12.464152. asking for a concerned friend who took the vaccine. That being said, most vaccines are essential for health but with these covid vaccines there has been a suspension of scepticism and government and corporate coercion that is extremely alarming. overreaction seen in some COVID-19 patients. There is some evidence that the spike proteins generated by the Moderna Covid-19 vaccine leave the site of injection. Nor is it known if one can have no visible symptoms but still have blood related disease that is not visible, or perhaps is not recognized for years. Episode 41. combine CRISPR with an imaging technology, so that it will only That could explain why some people have strokes, and why some people have issues in other parts of the body. SciCheck Digest. Office of Communications. The process prepares the body against future infection. Why Parents, Teens, and Children Should Question the COVID-19 Vaccine. Canadian Covid Care Alliance. 30 Mar 2021. This process ultimately Wrapp, Daniel, et al. Science. This is how the immune system becomes ramped up against these degraded pieces of proteins. Until he approached it and looking down saw down into the earth and was alarmed. 12 June 2021. We thus hypothesised that SARS-CoV-2 could use the ACE2 receptor to infect a range of nonhuman, non-bat hosts. However, trillions (of these proteins) induced by the vaccine injection have the capacity to create damage in your vascular system. Low, Jia Ming, et al. My educated guess is this: Now that the vaccines are about to be used in kids as young as 12, I expect a more robust immune response and the presence of a better (faster) metabolism will translate into more immediate reports of adverse events among younger vaccine recipients the same group (with some exceptions!) Who committed such evil ? 5 Immune Response Some immune cells latch onto the spikes and produce antibodiesY-shaped molecules that will recognize spike proteins and block them from getting inside other cells. Reply. But theres absolutely no harm. Episode 41. . Press release, Government of Canada, Health Canada. So antibodies created against the spike protein won't harm your body, they will only target coronavirus. Accessed 29 June 2021. Furthermore if vaccine induced spike were pathogenic wouldnt we see a lot of illness following vaccination?, Finally, Bridle says there is evidence that the mRNA vaccines get transferred through breast milk, citing apreprint from Singapore that tested milk samples from 10 lactating health care workers after they were immunized with the Pfizer/BioNTech vaccine. No vaccine is perfectly safe. It is a calculated risk. I have not seen any data to support what Bridle claims., Bridle, who in the radio show said hes very much pro-vaccine, says his claims are completely backed up by peer-reviewed scientific publications in well-known and well-respected scientific journals.. The research findings will impact predictions of COVID patients disease course when they check in to the hospital and finding the right treatment to accelerate recovery. Walt said the study found tiny concentrations of the spike protein in the first five days following vaccination, which showed that the body was producing the protein as intended.Crucially, these . No Evidence Vaccine-Generated Spike Protein Lingers in Bloodstream, Bridle is taking our results and completely misinterpreting them, said. inflammatory proteins called cytokines, colloquially known as Im wondering what this research implies about mRNA vaccines that stimulate the production of spike proteins. Why cant people sue pharmaceutical companies if they have disabling reactions or their family members die from it? An open space or just an open window could reduce the virus transmission. The mrna enters a cell (also in the brain, thanks to the lipid hull). A new vaccine for Covid-19 that is entering clinical trials in Brazil, Mexico, Thailand and Vietnam could change how the world fights the pandemic. Also you become able to look down into the middle of the earth. Watch this explanation. Even if the spike protein was absorbed into the blood stream, it has no mechanism of action to cause any issues such as bleeding disorders., According to the CDCs website there is limited data available on the safety and the effects of vaccination in lactating people or breastfed babies because the clinical trials didnt include people who were breastfeeding. When the cell dies, the spike protein is released.https://www.nytimes.com/interactive/2020/health/moderna-covid-19-vaccine.html, Wrong. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal modelproving that the spike protein alone was enough to cause disease. The truth is that the COVID-19 vaccine encourages the body to create copies of the spike protein found on the coronavirus's surface. spike protein, SARS-CoV-2 Angiotensin-Converting Enzyme 2 Grant support R01 HL106579/HL/NHLBI NIH HHS/United States . SARS-CoV-2 spike NTD to RBD Protein Vaccine Improves Immunity Against Viral Variants, iScience (2023). 8 June 2021. 2. your beta cells then process and read the enzyme with the mrna of the spike to watch out for the foot that will cause all this damage. According to a statement sent to FactCheck.org by the National Institute of Allergy and Infectious Diseases, the vaccine-generated spike protein is not secreted into circulation in the bloodstream.. the types of memory T and B cells that form in the lung These vaccines have been found to be effective and safe in clinical trials with tens of thousands of participants, and in real world conditions with over 325 million doses administered. In the new study, the researchers created a pseudovirus that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Email sent to FactCheck.org. . Updated 9 June 2021. Bridle, Bryam. 21 May 2021. transformative vaccines and gene therapies. If you have access to any vaccine, please take it, they are all good to protect you and your loved ones. Your partnership allows our scientists to accelerate the pace of high-risk, high-reward discoveries that have the potential to benefit the health of all humanity-be it cancer, Alzheimers disease, climate change, infectious diseases or more. Another monitoring system is the CDCs Vaccine Safety Datalink, which uses electronic health data from nine health care organizations in the U.S. to identify adverse events related to vaccination in near real time. (This also results in antibody production as others are correctly pointing out.). Its very safe, says WHOs Chief Scientist Dr. Soumya Swaminathan on a podcast produced by the organization. 6. Yes, and thats why it can make you a little ill. 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The Strange Truth About Clevelands Armor-Plated Prehistoric Sea Monster, on "COVID-19 Is a Vascular Disease: Coronavirus Spike Protein Attacks Vascular System on a Cellular Level", Newly Discovered Virus-Cell Interaction May Explain COVID-19s High Infection Rate, Caltechs Nanoparticle Vaccine Protects Against a Wide Range of COVID-19-Causing Variants and Related Viruses, Blood Test Can Track the Evolution of COVID-19 Coronavirus Infection, Chewing Gum Developed That Could Reduce COVID Transmission Laced With Protein That Traps the SARS-CoV-2 Virus, COVID Spike Protein Binds to Hearts Vascular Cells May Contribute to Severe Microvascular Damage, Beyond Omicron: Scientists Set Sights on Long Game of COVID Evolution, Tricking COVID-19 With a Fake Handshake to Inactivate the Coronavirus, Hunt for an Effective Treatment for COVID-19 Leads to Llamas & Their Special Antibodies, https://www.nytimes.com/interactive/2020/health/moderna-covid-19-vaccine.html, https://www.youtube.com/watch?v=9EfToFXwx98, https://www.aljazeera.com/news/2021/5/3/india-covid-cases-near-20-million-uk-to-send-more-aid-live-news, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/975909/S1182_SPI-M-O_Summary_of_modelling_of_easing_roadmap_step_2_restrictions.pdf, https://www.npr.org/2021/02/09/965703047/vaccines-could-drive-the-evolution-of-more-covid-19-mutants, https://www.regulations.gov/document/FDA-2020-N-1898-0246, https://www.jpost.com/health-science/could-an-mrna-vaccine-be-dangerous-in-the-long-term-649253, https://pubmed.ncbi.nlm.nih.gov/33053430/, https://pubmed.ncbi.nlm.nih.gov/33328624/, https://www.dailymail.co.uk/news/article-9366963/Coronavirus-Pfizers-Covid-vaccine-linked-blood-clots-AstraZenecas-UK.html, https://www.timesofisrael.com/real-world-israeli-data-shows-south-african-variant-better-at-bypassing-vaccine/, https://clinicaltrials.gov/ct2/show/NCT04311697, https://www.nih.gov/news-events/news-releases/clinical-trial-therapeutics-severely-ill-hospitalized-covid-19-patients-begins, https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827936/#:~:text=SARS%2DCoV%2D2%20uses%20its%20viral%20membrane%20fusion%20protein%2C,(ARDS)%20%5B5%5D, Mysterious Object Is Being Dragged Into the Milky Ways Supermassive Black Hole, Alzheimers and Other Undruggable Diseases Could Be Treated With Degraded Modified Proteins, Physics of Superpropulsion: Super-Fast Sharpshooter Insect Urination Using a Butt Flicker, Suppressing Symptoms A Neuro-Chip To Manage Brain Disorders, Unlocking the Mystery of Unconventional Superconductivity: A Breakthrough Experiment, The Search for Extraterrestrial Life: Machine Learning Uncovers Previously Undetected Signals of Interest, Alarming Findings: Most U.S. Children Use Potentially Toxic Cosmetic and Body Products, Astronomers Show There Are Four Classes of Planetary Systems, Harvard-Smithsonian Center for Astrophysics. In the absence of the protein EPS8, stereocilia are too short to . (See our Email Privacy Policy for details.) Walt told us in an email that the aim of the study was to see if an ultrasensitive detection technology, a single-molecule array, could detect circulating antigen produced by the mRNA vaccine to demonstrate the vaccine is working as designed. Salk Institute Verified account @salkinstitute. Those instructions tell the cell to make spike proteins. while a professor at the Salk Institute, Holley shared the Nobel Prize for his work on how these . Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own. Updated 29 June 2021. via rigorous testing in clinical trials prior to authorization or approval, followed by continued safety monitoring once the vaccine is rolled out to the public to detect potential rare side effects. Preprint Authors Email sent to FactCheck.org. American Journal of Obstetrics & Gynecology. The study, in which researchers administered a pseudovirus to hamsters, found the spike protein alone can damage vascular endothelial cells. But as the authors mention, the use of a pseudovirus is a limitation and findings need to be confirmed with the SARS-CoV-2 virus in the future. Heres a step-by-step guide to how they work. Every cure has a starting point. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented. To use a vaccine that induces a persons cells to manufacture a pathogen in the trillions seems foolish on the face of it. He posted a good link. We show here that S protein alone can damage vascular endothelial cells (ECs) in vitro and in vivo, manifested by impaired mitochondrial function, decreased ACE2 expression and eNOS activity, and increased glycolysis. Continue with Recommended Cookies, Representative images of vascular endothelial control cells (left) and cells treated with the SARS-CoV-2 Spike protein (right) show that the spike protein causes increased mitochondrial fragmentation in vascular cells. Pharmacokinetics is the study of how a drug moves through the body, including how quickly drugs are absorbed, metabolized, and excreted. The solution for the problem with Covid19 is Zyesame/Aviptadil. . Canadian Covid Care Alliance. Centers for Disease Control and Prevention. There is no evidence that the spike protein in vaccines is toxic or that it lingers at any toxic level in the body after vaccination, an FDA spokesperson told us in an email. They spent 12 years solving a puzzle. Mar 2020. These efforts range from understanding the structure of the virus to mobilizing the bodys immune reaction. There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it. This frees the (likely many) whole and partial spike proteins inside the cell into the blood. How the mRNA vaccines work to fight COVID-19. See: https://www.regulations.gov/document/FDA-2020-N-1898-0246. Accessed 29 June 2021. In addition to Salks ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. My statement that the spike protein migrates to the surface of the cell so as to be recognized by the immune system is not a very accurate simplification. A post widely shared on social media claims a viral immunologist said COVID-19 vaccines' spike protein means people are being inoculated "with a toxin." Experts say there is no evidence that the . 01 Professor Susan Kaech, who studies how we develop immunity to severe viral infections, such as chances of spreading. And look into the heavens and see the sun and all the stars in Heaven. Covid makes most people not ill at all or a little ill as well.No one knows that. Meanwhile, the Department of Justice is investigating myocarditis (inflammation of the heart) following cases in vaccinated service members. They travel extensively through the lymph system and a large number end up in the spleen. Professor of microbiology at the Perelman School of Medicine at the University of Pennsylvania. What leads you to believe that the spike protein will remain in the cell vs. expressed into the surrounding tissue by which not only antibody response will be built up (a good thing) but also attack by NK cells (another aspect of the immune system) and thus pro-thrombotic, pro-inflammatory aftereffects? Incredible this document is even published. Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. COVID-19 spike protein damages blood vessels The "spike" proteins that the coronavirus uses to help it break into cells inflicts other damage as well, according to a new study that shines a. Some one in the scientific community must comment on the joint sites of cooperationof the research and the varied nationality of the scientists working on the project! , have subsequently identified only a few, very rare adverse events. So if I took a vaccine, those spike proteins would bypass the first layers of my immune system and will do their damage right in the core of my body. Only small fragments of the ubiquoitim proteosome protein degradation process of the induced spike protein are presented on the surface of the cell by the MHC 1 ANTIGEN presentation system. Which is totally different from the wild version. with the Sanford Burnham Prebys Medical Discovery Institute You dumb asses also watched too much resident evil and think thats actual science and it shows. The Salk Institute's study concluded that Covid-19 vaccines are an effective and safe way to protect people from the virus. 28 May 2021. Kelly, Jeannie. Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others. The findings help explain COVID-19s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies. There is no screening or vetting of the report and no attempt to determine if the vaccine was responsible for the problem. Every cell invaded by the vaccine mRNA will eventually be destroyed by the immune system releasing spike protein. Much like any other vaccination in a breast feeding person, even if the spike protein makes it into the milk, the protein would be degraded by the stomach acid. Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together. 2 today, but of SARS-CoV-3 tomorrow. Would these vaccines not cause similar harm? , a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for. To fuse its viral membrane with the host cell membrane it substantially changes its shape from an unstable pre-fusion state to a stable post-fusion state. 14 June 2021. Word of caution re long term safety and giving the vax to young people The PAH survival is 3 years.Im one of those skeptical regarding the vaccines, yet I took the first dose of Pfizer. The study's last sentence says that when someone receives a. More confirmation watch this: https://youtu.be/9EfToFXwx98?t=479. [email protected]. in vaccinated individuals to establish benchmarks for The mRNA lipid coated vesicles (numbering in the trillions from the jab also enter the blood stream where they travel the whole body even past the blood brain barrier. We found we could detect extremely low concentrations of S1 (a subunit of spike) in 11 of 13 healthy vaccinated individuals and the full spike in 3 of 13, he said in an email, noting that the technology they used is 1,000 times more sensitive than a typical antigen test, so we are really detecting minute quantities of the spike and S1 proteins. (Emphasis is his). Health Canada authorizes use of the Pfizer-BioNTech COVID-19 vaccine in children 12 to 15 years of age. Press release, Government of Canada, Health Canada. Around 100,000 higher from natural infection versus vaccines. Professors Clodagh OShea, The vaccines are clearly beneficial to elderly people but I would never let my children be vaxxed without long term studies. This is concentrated in the lungs to help you to breath. Your support will accelerate the pace of breakthroughs in understanding disease and pave the way to new drug therapies. The vaccine has a limited number of spike proteins, and since its not part of a virus it cannot reproduce. Keanna Ghazvini, a Pfizer spokesperson, told us in an email that the, referred to by Bridle, which is mostly in Japanese, is a, overview of the companys vaccine. This treatment will prevent the virus For more, see How safe are the vaccines?. However, the model does not account for variants. LA JOLLAScientists have known for a while that SARS-CoV-2s distinctive spike proteins help the virus infect its host by latching on to healthy cells. Binding occurs in the pre-fusion state. Yes. We and our partners use data for Personalised ads and content, ad and content measurement, audience insights and product development. Her lab will also test Spokesperson, Pfizer. Shyy, 31 March 2021, Circulation Research.DOI: 10.1161/CIRCRESAHA.121.318902. As the old saying goes, where there is smoke there is fire. In elderly patients who are not already on deaths door, tolerance appears to be quite good (less, even, of flu-like symptoms post vaccination). This is cellular biology 101. 01 Professor Juan Carlos Izpisua Belmonte is collaborating with Theres been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Jason McLellan, a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for years and whose work was fundamental for the development of COVID-19 vaccines, said Bridles statements are not correct. The document was part of the submission data applied by Pfizer to PMDA (Japans version of FDA) for its review, and it is publicly available online, Ghazvini said. In 1964, American biochemist Robert Holley became the first person to isolate transfer RNA (tRNA)molecules that help mRNA build proteinsand map its structure. Professor Greg Lemke is delving into how receptors regulate the immune response and is studying ways to prevent the cytokine storms that develop in COVID-19, as the body produces such an overwhelming immune response in the lung that the collateral damage can be lethal for patients. My assumption is that it depends on the number of virus particles the person receives within a certain period.If you get in a close contact with someone who has already contracted the virus and spend hours together (like in a hospital room or a small office) theres a high chance for both to replicate and exchange the virus back and forth more and more exponentially and overloading your bodies before their immune systems respond. The spike protein encoded by the mRNA vaccines (Moderna and Pfizer/BioNTech) and the J&J vaccine instruct the cells in our arm (where the injection is given) to produce spike protein that is tethered to the surface of the cell. Retweeted. Accessed 29 June 2021. The Pfizer/BioNTech and Moderna vaccines carry instructions to produce a variant of the spike protein that has been locked into whats called a prefusion-stabilized conformation. who would not be expected to be at high risk from COVID-19 itself. 02 In addition, Izpisua Belmonte led a team of multi-institution scientists to develop a new viral screening test that can not only diagnose COVID-19 in a matter of minutes with a portable, pocket-sized machine, but can also simultaneously test for other viruseslike influenzathat might be mistaken for the coronavirus. At the same time, clinicians can sequence the virus, providing valuable information on the spread of COVID-19 mutations and variants. Email sent to FactCheck.org. Honestly i think you have a bigger problem to worry about then the vaccine Bailey. In fact, the antibodies that the mother has can go through the breast milk to the baby and may only serve maybe to protect the baby a little bit. , COVID-19 Vaccination Considerations for ObstetricGynecologic Care. Researchers detected levels of SARS-CoV-2 protein as early as one day after the first injection in 11 of the 13 participants. COVID-19 Vaccines While Pregnant or Breastfeeding. 9. So solving the issues of viruses and other harmful parasites.Can be overcome by locating this sea.There is one man who saw this sea. How long exactly, do Pfizer protocol cover this? And since elderly people are at increased risk of COVID-19 complications, it makes more sense for them to be vaccinated than not. . This is an a synthetic form of Human Vasoactive Intestinal Polypeptide (VIP). Updated 29 June 2021. All Rights Reserved. You walk in the park and an infected person coughs near you, so you manage to get few virus particles but keep walking and breathing fresh air. The researchers will use From having a large garden to investigating compounds that plants make, Staff Scientist Pam Maher talks about how plants inspire her to find treatments for Alzheimers disease.

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