1993 Apr; 264(4 Pt 1):G589-95. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. 2015 Sep; 42(5):582-90. 2012 Jul; 36(1):22-9. J Biol Chem. Role of NADPH oxidases in liver fibrosis. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Yale J Biol Med. Biotechniques. 2008 Mar; 23 Suppl 1:S98-103. 2005 Sep; 230(8):573-86. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. J Hepatol. Hepatobiliary Surg Nutr. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. 2013 Apr; 20(4):649-58. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Gastroenterology. We lose people all of 2015 Jul; 22(7):512-8. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 1998 Sep; 13(S1):S39-S50. 1995 Sep; 9(9):1157-65. Cell. Heterogeneity of HSCs in a Mouse Model of NASH. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Hepatol Commun. Hepatology. 1999 09; 277(3):G671-7. Mechanisms of fibrogenesis. 2002 Oct; 4(5):769-81. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Hepatitis C and alcohol: fundamental and translational research directions. Am J Physiol Gastrointest Liver Physiol. Biochem Biophys Res Commun. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. 2013 Jun; 45(6):450-9. Involvement of death receptor-related signaling pathways. 2000 Mar-Apr; 21(2):135-41. Liver Int. Mol Cell Biol. 2015 Apr 06; 212(4):469-80. Gastroenterology. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. A simplified method for the preparation of transcriptionally active liver nuclear extracts. 1989 Aug 15; 49(16):4446-51. 2004 Nov; 40(5):1151-9. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. 2011 May; 53(5):1433-5. 2004 Oct; 121(2):159-70. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. 2007 Mar; 14(3):568-75. Int J Mol Sci. Analysis of the collagen alpha 1(I) promoter. medRxiv. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. 1999; 8(3):151-63. Nucleic Acids Symp Ser. J Clin Invest. 2016 Aug; 38(4):291-302. 2013 Mar 01; 3(1):4-11. Nat Rev Gastroenterol Hepatol. Nephron. Mol Cell Biol. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. 2017 01; 65(1):78-88. 2006 Aug; 116(8):2058-9. JCI Insight. Hepatology. 2012 Nov; 67(11):1357-64. 2001 May; 25(5 Suppl ISBRA):251S-253S. Ceramide activates the stress-activated protein kinases. 2018 09; 68(3):918-932. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. AIDS. PLoS One. J Hum Nutr Diet. UCSD Profiles is managed by the UC San Diego Gastroenterology. 2014 Jan; 59(1):19-20. J Immunol. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Ann Hepatol. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. People in Profiles who have published with this person. Am J Pathol. 2003 Apr; 27(4):726-31. 1991 Mar; 5(3):275-81. J Hepatol. Cell Death Differ. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Dig Dis. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. 2021; 16(12):e0260721. Surgery. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Cell Metab. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. 1998 Sep; 13(S1):S93-S95. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. J Bone Miner Res. Gastroenterology. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Gastroenterology. 2019 01; 17(2):218-230. 2006 Sep; 291(3):G456-63. 2000; 35 Suppl 12:80-3. Am J Physiol. Nuclear factor-kappaB in the liver: friend or foe? Molecular and cellular biology of the small intestine. Blood. Liver Transpl. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. J Am Coll Cardiol. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Nat Commun. J Clin Invest. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. 2006 May; 130(6):1886-900. Moderate alcohol drinking: effects on the heart and liver. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. 1989 Sep; 30(9):1220-4. 2014 Jun 10; 20(17):2854-72. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology. Alzheimer's disease: the vascular connection. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Science. Cell Host Microbe. Ital J Gastroenterol Hepatol. 1987 Sep; 79(3):449-56. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Molecular epidemiology and cancer prevention. WebBrenners new job suits his eclecticism. J Clin Invest. Genomics of liver fibrosis and cirrhosis. J Hepatol. 2000 Apr 21; 275(16):12207-13. 2013 Mar; 37(6):630-9. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. 2003 Apr; 38(4):468-75. 2017 12; 1(10):1043-1057. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. 2016 08; 65(2):369-76. The future of gastroenterology and gastroenterology. PLoS One. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Derived automatically from this person's publications. 2007 Dec; 133(6):2019-28. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Gastroenterology. Nucl Med Biol. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Hepatology. J Immunol. 2000 Nov; 119(5):1399-401. 2002 Dec; 36(6):1498-508. 1998 Jun; 42(6):779-87. What goes up must come down: the emerging role of microRNA in fibrosis. Antioxid Redox Signal. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. David has 2 jobs listed on their profile. 2002 Jul; 283(1):G204-11. 2019 07 23; 116(30):15184-15193. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. A logical approach to the patient with jaundice. 2019 09; 71(3):573-585. 2010 Mar; 51(3):1027-36. Clin Gastroenterol Hepatol. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. J Hepatol. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Gastroenterology. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. J Hepatol. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Dig Dis. Hum Mol Genet. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Hepatology. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Liver fibrogenesis: a new role for the renin-angiotensin system. 1998 May; 114(5):1035-45. Liver Int. 2008 Nov; 135(5):1729-38. 2021; 12(3):891-920. Dig Dis Sci. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. 2020 01 07; 31(1):189-206.e8. Nature. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Hepatology. Gastroenterology. 1992 Feb 28; 183(1):184-92. Mechanisms of hepatic toxicity. 2000 Feb; 31(2):391-8. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Biol Chem. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Hepatology. 2003 Oct; 23(5):386-96. Mol Biol Med. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus 2011 Jul; 41(7):683-6. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Hepatology. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. 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