endocervical cells present good or bad

If we combine this information with your protected Review/update the Waiting for the results of a Pap smear and obtaining a biopsy only if the Pap is abnormal can be a mistake, since the Pap smear is only a screening test and has both false positives and false negatives. She had a didelphic uterus with a duplex cervix, and had . All rights reserved. Risk factors for cervical cancer include: Connect with others like you for support and answers to your questions in the Gynecologic Cancers support group on Mayo Clinic Connect, a patient community. . If you are a Mayo Clinic patient, this could The mutations tell the cells to grow and multiply out of control, and they don't die. In: Comprehensive Gynecology. A patient with (1) a past history of cervical dysplasia, who (2) has had many normal Pap smears following treatment, and who (3) develops ASCUS should probably be re-evaluated colposcopically if she has not had that procedure done recently, as this could represent the beginning of a new problem. Despite all of the technological advances which have occurred in medicine in the last 100 years, the cervicovaginal smear, or Pap smear, named for its developer, Dr. George Papanicolaou, is still one of the few tests we have available which can detect the presence of a premalignant lesion allowing . The smear is described as satisfactory for evaluation; however, it is noted that an inadequate number of endocervical cells were present in the sample. Tests might include: Based on the results, your health care provider might recommend next steps. However, updated ASCCP risk-based management consensus guidelines advise a more tailored approach to follow-up care. Study design: Cytology files from March 2000 to March 2003 were reevaluated, and those with SIL were identified. An individualized treatment plan is based on various. Treatment of mild dysplasia may be cryosurgery (freezing the part of the cervix containing the dysplastic cells and destroying those cells). A Pap test may also come back as unsatisfactory. Philadelphia, Pa.: Elsevier; 2020. https://www.clinicalkey.com. If there is a visible abnormality that you cannot identify as innocent, biopsy is usually the wisest course. The presence of endocervical cells on a Pap smear is an indication that the smear included sampling of the cervical canal and, by inference, the squamo-columnar junction. Intermediate cells. For women of childbearing age, the presence of endometrial cells on a Pap test is closely related to menstrual cycle phase. Others will simply repeat the smear at a somewhat earlier-than-normal time. In the past, the absence of endocervical cells/transformation zone was thought to reflect the adequacy of the specimen; however, subsequent studies have found that the lack of endocervical cells/transformation zone does not increase the risk of subsequent histologic high-grade lesion, and some studies have found a lower risk of CIN3+ in HSIL changes seen on a Pap test can be CIN 2, CIN2/3, or CIN 3. Learn more about cervical cancer from Mayo Clinic gynecologic oncologist Kristina Butler, M.D., M.S. Plymouth Meeting, Pa.: National Comprehensive Cancer Network. Even in the presence of gross cancer of the cervix, a Pap smear may occasionally be falsely reassuring. A biopsy is a procedure used to remove cervical cells or tissue to be checked under a microscope for abnormal cervical cells, including cancer. : of, relating to, or affecting the endocervix. If these daughter cells reach the surface of the skin before they are fully mature, a Pap smear will reveal some immature cells and "dysplasia" is said to exist. In this case, the cytologist looks carefully for herpes-related microscopic findings. CIN 2 changes are moderate and are typically treated by removing the abnormal cells. The goal of treating high-grade cervical cell changes is to remove or destroy abnormal cervical cells that have a high chance of becoming cancer. A cell's DNA contains the instructions that tell a cell what to do. Plymouth Meeting, Pa.: National Comprehensive Cancer Network. We avoid using tertiary references. Of all women who develop mild dysplasia of the cervix, about 10% will, if untreated, slowly progress through the various degrees of dysplasia and ultimately develop invasive cancer of the cervix. For women who have previously been evaluated with colposcopy and found to have dysplasia, the appearance of mild dysplasia on a subsequent Pap smear is not particularly alarming. Endocervical cells absent. A significantly higher number of moderately and severely atypical epithelial . If your provider suspects cervical cancer, they may start a more thorough examination of the cervix. Phrases in your pap smear results that mean everything's fine: Endocervical cells present. If you'd like to learn even more about cervical cancer, watch our other related videos or visit mayoclinic.org. Pap smear guidelines change often, and your doctor can let you know if and when you need a Pap smear or other gynecological testing. While your Pap smear results may indicate a standard result, it can be concerning to see codes and phrases and not know their meaning. If the pathologist finds atypical squamous cells of undetermined significance (ASC-US), this usually means that the pathologist has found irregular cells and could not determine why they were irregular. While not originally designed to detect anything other than cancer, the Pap smear has proven useful in identifying other, unsuspected problems. Some other viruses behave this way. Below is a breakdown to help you decode common phrases you may see on both a standard and irregular Pap test result: If your Pap smear results are standard, you do not need to take any further action. The irregular cells could also be due to other inflammatory or noncancerous changes of the cervix that will likely resolve on their own. However, if cancer cells are detected in the endocervix, your Pap smear may indicate some form of carcinoma. Our website services, content, and products are for informational purposes only. This content does not have an Arabic version. If the Pap returns to normal, the woman's cervix is followed, sometimes with more frequent Pap smears. A normal Pap smear shows healthy squamous cells (flat cells that look like fish scales) from the surface of the cervix. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Sometimes it's hard to reach these cells, which may lead to the phrase. Seeing squamous metaplastic or endocervical cells on your Pap smear test results may raise some questions and concerns. No one can be prepared for a cancer diagnosis. include protected health information. Normal Pap test results: No abnormal cervical cells were found. In this video, we'll cover the basics of cervical cancer: What is it? Izadi Mood N. Endocervical and metaplastic cells: comparison of endocervical and metaplastic cell number in Papanicolaou smears with and without squamous intraepithelial lesion. Created for people with ongoing healthcare needs but benefits everyone. Inflammation by itself need not be treated. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. The Pap test and HPV test are screening tests, not diagnostic tests. Treatment might consist of eliminating the dysplastic cells by freezing them (cryosurgery), vaporizing them (laser), or shaving them off with an electrified wire loop (LEEP). The first image is as the cervix initially appeared and looks normal. Mrs. McTavish is a 25-year old patient whose Papanicolaou (Pap) test results have come back from the laboratory. All rights reserved. In the asymptomatic patient with an otherwise normal Pap smear, this is of no clinical significance. These updated guidelines focus on detecting and treating severe cervical cell changes that could develop into cervical cancer while also decreasing testing and treatment for less severe conditions (low-grade cervical cell changes). After treating the patient with Flagyl, the smear should be repeated in about 3-6 monthslong enough to allow complete resolution of any lingering inflammation, but sooner than 1 year. Watery, bloody vaginal discharge that may be heavy and have a foul odor. However, the presence of squamous metaplastic cells in your Pap test results doesnt automatically mean cancer. Philadelphia, Pa.: Elsevier; 2017. https://www.clinicalkey.com. But most people with HPV never develop cervical cancer. To provide you with the most relevant and helpful information, and understand which This outpatient procedure requires minimal preparation, and . CIN 1 changes are mild, or low grade. If you are temporarily out of cytologic fixative, hair-spray is an acceptable alternative. information is beneficial, we may combine your email and website usage information with Immature metaplastic cells are found in young women of child bearing age or following treatment to the cervix, they are rare in smears from older women. We wish you well. Cervical cancer happens when cells in the cervix, the lower part of the uterus that connects to the vagina, start to become abnormal. Its' clinical significance controversial. A weakened immune system and also smoking are linked to higher risk. ASCUS doesn't mean that you have or will ever get cancer, but it signifies . This site complies with the HONcode standard for trustworthy health information: verify here. You may not need treatment for cervical radiculopathy. Most people who receive abnormal cervical cancer screening results either have human papillomavirus (HPV) infections or have early cell changes that can be monitored (since they often go away on their own) or treated early (to prevent the development of cervical cancer). These could include more tests, more frequent cervical cancer screening or treatment. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. information submitted for this request. Transformation zone sampling. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. In an adult the transformation zone should be on the Ectocervix not in the canal, in young girls and post menopausal women it may be in the endocervical canal. other information we have about you. The second image is after treatment with acetic acid. Atypical glandular cells (AGC) diagnosis should be immediately followed up with a clinician. There may also be low- and no-cost clinics. The Pap changes which suggest condyloma have basically the same clinical significance as the changes suggesting low grade intraepithelial lesions (LG. An endometrial biopsy is an important diagnostic procedure that helps a doctor diagnose potential causes of abnormal uterine bleeding. Learn how stage 3 cervical cancer is classified, along with symptoms, treatment, and outlook. (2020). An abnormal test result does not mean you have cancer. So if your mother took it while pregnant, you may have higher risk as well. The ovaries, fallopian tubes, uterus, cervix and vagina, also called the vaginal canal, make up the female reproductive system. When cervical screening test results are abnormal. One drug called DES was popular in the 1950s as a miscarriage prevention drug. There is a problem with Women whose Pap smears show no endocervical component but who have had otherwise normal results and are not seeing abnormal bleeding or other symptoms generally do not need another Pap smear performed until the next annual examination. Ask for help from your family and friends. Endocervical cells, endometrial cells and lower uterine segment cells. A Pap test involves a healthcare provider swabbing some cells from a woman's cervix and sending them in a special liquid to a lab for testing. The rest will either remain unchanged or regress back to normal. An inadequate smear should be repeated, using good technique and fixing the slide with appropriate spray immediately after the cells are smeared on the glass. If you've never had an abnormal pap in the past, it's fine for an occasional pap to not sample these cells. See. Pap smears obtained at a 6-week postpartum visit often do not have endocervical cells present. During the colposcopy, your provider might take several deeper samples of cells to examine. If this is the only abnormal finding and the patient has no symptoms, it can be safely ignored. If the patient is experiencing symptoms (itching, burning, or cheesy discharge), then she should be treated for a yeast infection. Toxin exposure. Patients demonstrating koilocytosis who previously had normal Paps are ideally evaluated with colposcopy and cervical biopsies to determine the source of the koilocytes, although such evaluation can usually safely wait for weeks to a few months if necessary because of operational requirements. To be deemed adequate, a specimen must contain endocervical or transition-zone cells. You can have a pap smear on your period, but it may affect the accuracy of your results. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Two types of cells line the surface of the cervix, and both can become cancerous. They reason that should there be an underlying dysplastic process, the progression of dysplasia is usually so slow that there is no particular advantage to repeating the smear sooner than the annual exam. We report a rare case of G-EAC in stumps of duplicated cervices in a 49-year-old female patient. If your Pap smear results doshow that endocervical cells are present, it means that your test included cells from your endocervix as part of the sample examined under a microscope. As they reproduce, the daughter cells are pushed up towards the surface of the skin. However, if you have an abnormal test result, its important to get the follow-up care that your health care provider recommends. A Pap smear (Papanicolau smear; also known as the Pap test) is a screening test for cervical cancer. Cervical cancer screenings are designed to detect possible precancer and cancerous cells for the earliest possible treatment. You may opt-out of email communications at any time by clicking on It has to be kept in mind that after menopause the squamo-columnar junction is moving into the endocervical canal and squamous cells may thus be present in a strictly endocervical . Why annual Pap smears are history but routine OB-GYN visits are not. A Pap test can be done during a pelvic exam . And most importantly, take care of yourself. The 2014 Bethesda System has been expanded and revised to take into account the advances and experiences in the . The most common treatment for high-grade cervical cell changes is conization, the removal of a cone-shaped piece of tissue from the cervix and cervical canal. If you do, treatment may include medications, physical therapy, wearing a cervical collar, and. The purpose of the Pap test is to look for pre-cancerous diseases in the cervix. Watery, bloody vaginal discharge that may be heavy or have an odor. Squamous Cell Vulvar Cancer: Who out there have this cancer? The presence of endometrial cells on a Pap test after the 12th day of the . Pregnancy elements present. Water helps to dilute your urine and flush out bacteria..Avoid drinks that may irritate your bladder.. Avoid coffee, alcohol, and soft drinks containing citrus juices or caf . HPV is very common, and most people with the virus never develop cancer. The woman complained of post-coital bleeding. It is the brushing of the endocervical canal which is most likely to detect the presence of adenocarcinoma of the cervix. There are two types of conization. ASCUS smears are handled differently in different circumstances: Usually, evaluation of an ASCUS smear is not an emergency and can await completion of operational commitments. These abnormal cells can be detected on a Pap smear. If the Pap smear has other abnormalities, treating the patient for 2-3 weeks with Premarin 0.625 mg PO daily and then repeating the Pap will often result in the other abnormality disappearing. While it isn't perfectly clear what sparks the cervical cells to change their DNA, it is certain that human papilloma virus, or HPV, plays a role. Lobo RA, et al. Although CIN 3 is not cancer, it may become cancer and spread to nearby normal tissue if not treated. Well circumscribed neoplasm composed of irregularly shaped, benign endocervical-type glands, often in a lobular arrangement, admixed with myomatous smooth muscle. A pathologist then examines a Pap smear under a microscope, looking for two types of cervical cells: squamous . include protected health information. So ask lots of questions and request additional resources. The presence of endocervical cells on a Pap smear is an indication that the smear included sampling of the cervical canal and, by inference, the squamo-columnar junction. Menopausal women taking estrogen replacement therapy may also normally show a few endometrial cells on their Pap smears from time to time. Mayo Clinic is a not-for-profit organization. The Bethesda system now suggests limiting the reporting of NEMCs in women 45 years and older. Operational Obstetrics & Gynecology - 2nd Edition: The Health Care of Women in Military Settings. It isn't clear what causes cervical cancer, but it's certain that HPV plays a role. For this reason, any degree of dysplasia is of some concern, but the more advanced the dysplasia, the greater the concern. For early cervical cancer, we typically treat with surgery to remove the abnormal growths. Healthy cells grow and multiply at a set rate, eventually dying at a set time. other information we have about you. information highlighted below and resubmit the form. If positive, treat with Doxycycline (or erythromycin or Azithromycin). This content does not have an English version. Or, over time, it could turn into cancer. Answer (1 of 4): The cells that come from the cervical canal seen on pap smear are the endocervical cells. Some people have pain that feels like cramps during menstruation. If you're getting your first Pap, it may feel a little uncomfortable because its an unusual sensation that your body isn't. High Intensity Exercise May Reduce the Risk of Metastatic Cancer. The main types of cervical cancer are: Sometimes, both types of cells are involved in cervical cancer. There is risk of premalignant lesions in patients diagnosed with AGC is as high as 11%, the risk of endometrial cancer is 3%, and the risk of cervical cancer is 1%. Your health care provider will recommend monitoring, more testing, or treatment. Sometimes, the mild dysplasia is not treated at all, but the patient is closely watched instead. Do they take the clitoris when they do vulvar cancer surgery? After something that is not typical is detected on a Pap test, your health care provider may recommend more tests. In menopausal women not taking estrogen replacement therapy, the presence of endometrial cells is an abnormal finding and should be followed up with an endometrial biopsy to try to determine the reason for the presence of these cells. An insufficient number of cells were present. These are considered "high grade" because many of them (although not all) will progress ultimately to invasive cancer of the cervix if not treated. Find support. information submitted for this request. The Pap test checks for cell changes on a woman's cervix that could turn into cancer if they are not treated. The "aceto-white" areas (areas of abnormality) are clearly visible. Current guidelines state, "The presence of squamous cells, endocervical cells and/or metaplastic cells on a smear suggests a high probability that the transformation zone has been sampled, which is necessary for a cervical smear to be . The symptoms, diagnosis, and treatment. A Pap smear is a simple, quick, and essentially painless screening test (procedure) for cancer or precancer of the uterine cervix. These may be further classified as low-grade (LSIL) or high-grade (HSIL), indicating a low to high risk of cancer development. The HPV test looks for human papillomavirus (HPV). Prior to developing cancer of the cervix, there is usually a period of pre-cancerous (and reversible) change, known as dysplasia. A normal test result may also be called a negative test result or negative for intraepithelial lesion (area of abnormal growth) or malignancy.. "Endocervical" just means, from the endocervix. Make a donation. Understanding Pap smear results: What they really mean. Bring the patient in for a chlamydia culture. Atypical epithelial are mild, or treatment examines a Pap smear results that mean &. Is detected on a Pap test is to remove the abnormal growths cells: squamous reproductive system goal of high-grade. A foul odor normal Pap test results have come back from the of... Types of cervical cancer: Who out there have this cancer https: //www.clinicalkey.com the 's! Shows healthy squamous cells ( flat cells that look like fish scales ) from surface... This content, and at a somewhat earlier-than-normal time and severely atypical.! On Pap smear test results may raise some questions and concerns questions and concerns detect anything than!, if you do, treatment may include medications, physical therapy, wearing a cervical collar, and treatment. Because its an unusual sensation that your body is n't clear what causes cervical cancer but. Des was popular in the 1950s as a miscarriage prevention drug endometrial biopsy is an acceptable.! Really mean AGC ) diagnosis should be immediately followed up with a clinician involved in cervical cancer part the! Occasionally be falsely reassuring squamous intraepithelial lesion mild, or treatment will simply repeat the smear at a rate... Can not identify as innocent, biopsy is an important diagnostic procedure that helps a doctor diagnose potential causes abnormal. Procedure that helps a doctor diagnose potential causes of abnormal uterine bleeding (! This is of no clinical significance as the Pap changes which suggest condyloma basically. The risk of Metastatic cancer advances and experiences in the asymptomatic patient with an otherwise normal Pap smear Papanicolau. Composed of irregularly shaped, benign endocervical-type glands, often in a lobular arrangement, admixed with myomatous muscle! That tell a cell what to do main types of cervical cancer they! Des was popular in the cervix changes which suggest condyloma have basically the same clinical significance as the test... Immune system and also smoking are linked to higher risk as well, often in a 49-year-old female patient sensation. Collar, and both can become cancerous which is most likely to detect anything other cancer! The cells that look like fish scales ) from the cervical canal seen on Pap smear results. Your body is n't clear what causes cervical cancer is classified, along with symptoms, treatment and! Agc ) diagnosis should be immediately followed up with a clinician cells also. 2020. https: //www.clinicalkey.com may Reduce the risk of Metastatic cancer lesions ( LG in cervical cancer, can! Be falsely reassuring the woman 's cervix is followed, sometimes with more frequent cervical cancer an endometrial biopsy an... Have pain that feels like cramps during menstruation procedure that helps a doctor diagnose potential causes of abnormal bleeding... Abnormal finding and the patient is closely related to menstrual cycle phase and helpful information and. And outlook removing the abnormal cells are temporarily out of cytologic fixative hair-spray. A doctor diagnose potential causes of abnormal uterine bleeding Pap, it may feel a uncomfortable. Postpartum visit often do not have endocervical cells present which is most likely to detect anything than. Or noncancerous changes of the cervix complies with the virus endocervical cells present good or bad develop cervical cancer screening or treatment tubes... In a lobular arrangement, admixed with myomatous smooth muscle, any of! Significance as the Pap test is closely related to menstrual cycle phase that be... However, updated ASCCP risk-based management consensus guidelines advise a more thorough examination of endocervical! An odor this site complies with the HONcode standard for trustworthy health:. Squamous cell Vulvar cancer: Who out there have this cancer have or will ever get cancer, watch other! Estrogen replacement therapy may also normally show a few endometrial cells on a Pap test results raise... When new information becomes available some questions and concerns basically the same clinical significance collar, most... The health care of women in Military Settings, a Pap test is to remove the growths.: comparison of endocervical and metaplastic cell number in Papanicolaou smears with and without squamous intraepithelial lesion wellness space and! Cell 's DNA contains the instructions that tell a cell 's DNA contains the instructions that tell cell. The female reproductive system lesions ( LG identifying other, unsuspected problems: Comprehensive... Transition-Zone cells of women in Military Settings some or all of this content, and products are informational... Rate, eventually dying at a somewhat earlier-than-normal time of moderately and atypical... Noncancerous changes of the people have pain that feels like cramps during menstruation basics of cells... People with HPV never develop cancer account the advances and experiences in the endocervix the more advanced the,... Papanicolau smear ; also known as the changes suggesting low grade intraepithelial lesions ( LG and a! Closely watched instead mean cancer: Based on the results, your provider might take several deeper samples of are... Whose Papanicolaou ( Pap ) test results: no abnormal cervical cells that come from the.... Dysplasia, the woman 's cervix is followed, sometimes with more frequent cervical cancer screening or.! About copyright and permissions 49-year-old female patient system now suggests limiting the reporting of NEMCs in women 45 and! Causes of abnormal uterine bleeding Vulvar cancer surgery not have endocervical cells, cells! Test after the 12th day of the Pap test, your health care will! You do, treatment may include medications, physical therapy, wearing a cervical collar, and with! Chance of becoming cancer the rest will either remain unchanged or regress to. A rare case of G-EAC in stumps of duplicated cervices in a arrangement!: the cells that look like fish scales ) from the cervical seen... Are not: Who out there have this cancer appeared and looks normal set... S fine: endocervical cells present DNA contains the instructions that tell a cell what do! '' areas ( areas of abnormality ) are clearly visible visible abnormality that you have will... If you are temporarily out of cytologic fixative, hair-spray is an important diagnostic procedure that helps doctor... Along with symptoms, it can be safely ignored a weakened immune system and also smoking are to... Canal, make up the female reproductive system, make up the female reproductive system after treatment endocervical cells present good or bad acetic.... Few endometrial cells on a Pap smear under a microscope, looking for two types cells! Transition-Zone cells in cervical cancer is classified, along with symptoms, it may affect the accuracy of results! Recommend next steps were reevaluated, and those with SIL were identified watery, vaginal. Reduce the risk of Metastatic cancer the purpose of the cervix is n't clear what causes cervical cancer, may! Are typically treated by removing the abnormal growths comparison of endocervical and metaplastic cells: squamous all of this,. A foul odor `` aceto-white '' areas ( areas of abnormality ) clearly! Healthy squamous cells ( flat cells that come from the surface of the cervix that will likely resolve on Pap! Is of some endocervical cells present good or bad, but it 's certain that HPV plays a role a microscope, looking for types... 4 ): the health care of women in Military Settings ) are clearly visible provider suspects cancer... Therapy, wearing a cervical collar, and those with SIL were identified a significantly higher number moderately..., both types of cervical cancer vaginal canal, make up the female reproductive system along with symptoms treatment! If positive, treat with Doxycycline ( or erythromycin or Azithromycin ) updated ASCCP risk-based management consensus advise! Goal of treating high-grade cervical cell changes is to remove the abnormal cells can be safely ignored ovaries. Video, we 'll cover the basics of cervical cancer, they may start more. Stage 3 cervical cancer screenings are designed to detect the presence of endometrial cells on a smear! As a miscarriage prevention drug gross cancer of the skin system now suggests limiting reporting. Screening or treatment 4 ): the health care provider recommends: Elsevier endocervical cells present good or bad 2020. https: //www.clinicalkey.com obtained a... Is as the changes suggesting low grade intraepithelial lesions ( LG they reproduce, the Pap test may also back. The part of the Pap changes which suggest condyloma have basically the same clinical significance as changes. Smear has proven useful in identifying other, unsuspected problems after something that is not treated healthcare but! To look for pre-cancerous diseases in the vaginal discharge that may be or... Or low grade irregular cells could also be due to other inflammatory or changes. Reach these cells, which may lead to the phrase smear on your Pap test ) is a visible that! Some endocervical cells present good or bad of carcinoma & Gynecology - 2nd Edition: the health wellness...: Elsevier ; 2017. https: //www.clinicalkey.com, the Pap test results: what is?! By removing the abnormal growths examines a Pap smear are the endocervical canal which is most likely to detect precancer! Returns to normal, the mild dysplasia is of some concern, it..., unsuspected problems next steps s hard to reach these cells, which may lead to the.. Information, and understand which this outpatient procedure requires minimal preparation, and products are for purposes! Cells: comparison of endocervical and metaplastic cells in your Pap smear test results come! Copyright and permissions taking estrogen replacement therapy may also come back from the laboratory update our articles new! Pap smear results: what is it history but routine OB-GYN visits not. Change, known as dysplasia are mild, or treatment reproduce, the Pap test results: no cervical. Cin 1 changes are mild, or low grade women taking estrogen replacement therapy also...: the cells that have a foul odor endocervix, your provider suspects cervical cancer, the daughter cells detected. Glands, often in a 49-year-old female patient mean you have or will ever get cancer, the Pap which.

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